Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver
R Dentin, L Tomas-Cobos, F Foufelle, J Leopold… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: In liver, the glucose-responsive transcription factor ChREBP plays
a critical role in converting excess carbohydrates into triglycerides through de novo
lipogenesis. Although the importance of ChREBP in glucose sensing and hepatic energy
utilization is strongly supported, the mechanism driving its activation in response to glucose
in the liver is not fully understood. Indeed, the current model of ChREBP activation, which
depends on Serine 196 and Threonine 666 dephosphorylation, phosphatase 2A (PP2A) …
a critical role in converting excess carbohydrates into triglycerides through de novo
lipogenesis. Although the importance of ChREBP in glucose sensing and hepatic energy
utilization is strongly supported, the mechanism driving its activation in response to glucose
in the liver is not fully understood. Indeed, the current model of ChREBP activation, which
depends on Serine 196 and Threonine 666 dephosphorylation, phosphatase 2A (PP2A) …