[HTML][HTML] Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine
J Guo, S Longshore, R Nair, BW Warner - Journal of biological chemistry, 2009 - ASBMB
The function of retinoblastoma protein (pRb) in the regulation of small intestine epithelial cell
homeostasis has been challenged by several groups using various promoter-based Cre
transgenic mouse lines. Interestingly, different pRb deletion systems yield dramatically
disparate small intestinal phenotypes. These findings confound the function of pRb in this
dynamic tissue. In this study, Villin-Cre transgenic mice were crossed with Rb (flox/flox) mice
to conditionally delete pRb protein in small intestine enterocytes. We discovered a novel …
homeostasis has been challenged by several groups using various promoter-based Cre
transgenic mouse lines. Interestingly, different pRb deletion systems yield dramatically
disparate small intestinal phenotypes. These findings confound the function of pRb in this
dynamic tissue. In this study, Villin-Cre transgenic mice were crossed with Rb (flox/flox) mice
to conditionally delete pRb protein in small intestine enterocytes. We discovered a novel …