[HTML][HTML] Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo
T Pulinilkunnil, H He, D Kong, K Asakura… - Journal of biological …, 2011 - ASBMB
AMP-activated protein kinase (AMPK), an evolutionarily conserved serine-threonine kinase
that senses cellular energy status, is activated by stress and neurohumoral stimuli. We
investigated the mechanisms by which adrenergic signaling alters AMPK activation in vivo.
Brown adipose tissue (BAT) is highly enriched in sympathetic innervation, which is critical for
regulation of energy homeostasis. We performed unilateral denervation of BAT in wild type
(WT) mice to abolish neural input. Six days post-denervation, UCP-1 protein levels and …
that senses cellular energy status, is activated by stress and neurohumoral stimuli. We
investigated the mechanisms by which adrenergic signaling alters AMPK activation in vivo.
Brown adipose tissue (BAT) is highly enriched in sympathetic innervation, which is critical for
regulation of energy homeostasis. We performed unilateral denervation of BAT in wild type
(WT) mice to abolish neural input. Six days post-denervation, UCP-1 protein levels and …