[HTML][HTML] Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes: a role for a protein kinase B, LKB1, and AMP-activated protein …
SJ Kim, C Nian, CHS McIntosh - Journal of Biological Chemistry, 2007 - ASBMB
Glucose-dependent insulinotropic polypeptide (GIP) has been mainly studied because of its
glucose-dependent insulinotropic action and its ability to regulate β-cell proliferation and
survival. Considerably less is known about the effects of GIP on fat metabolism, and the
present study was directed at identifying the mechanisms underlying its stimulatory action on
lipoprotein lipase (LPL). In differentiated 3T3-L1 adipocytes, GIP, in the presence of insulin,
increased LPL activity and triglyceride accumulation through a pathway involving increased …
glucose-dependent insulinotropic action and its ability to regulate β-cell proliferation and
survival. Considerably less is known about the effects of GIP on fat metabolism, and the
present study was directed at identifying the mechanisms underlying its stimulatory action on
lipoprotein lipase (LPL). In differentiated 3T3-L1 adipocytes, GIP, in the presence of insulin,
increased LPL activity and triglyceride accumulation through a pathway involving increased …