[HTML][HTML] The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association …

M Tang, H Shen, Y Jin, T Lin, Q Cai, MA Pinard… - Journal of Biological …, 2013 - ASBMB
Chromatin readers decipher the functional readouts of histone modifications by recruiting
specific effector complexes for subsequent epigenetic reprogramming. The LSD1 (also
known as KDM1A) histone demethylase complex modifies chromatin and represses
transcription in part by catalyzing demethylation of dimethylated histone H3 lysine 4
(H3K4me2), a mark for active transcription. However, none of its currently known subunits
recognizes methylated histones. The Snai1 family transcription factors are central drivers of …