The nurd architecture
HF Allen, PA Wade, TG Kutateladze - Cellular and Molecular Life Sciences, 2013 - Springer
HF Allen, PA Wade, TG Kutateladze
Cellular and Molecular Life Sciences, 2013•SpringerThe nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin
organization, gene transcription, genomic stability and developmental signaling. NuRD has
a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among
its six core subunits. Recent studies indicate that NuRD composition and the interplay
between subunits may dictate the diverse functions of the complex. In this review, we
examine the structures and biological roles of the NuRD subunits and discuss new avenues …
organization, gene transcription, genomic stability and developmental signaling. NuRD has
a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among
its six core subunits. Recent studies indicate that NuRD composition and the interplay
between subunits may dictate the diverse functions of the complex. In this review, we
examine the structures and biological roles of the NuRD subunits and discuss new avenues …
Abstract
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the diverse functions of the complex. In this review, we examine the structures and biological roles of the NuRD subunits and discuss new avenues of research to advance our understanding of the NuRD-mediated signaling network.
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