[HTML][HTML] AG protein-coupled receptor responsive to bile acids

Y Kawamata, R Fujii, M Hosoya, M Harada… - Journal of Biological …, 2003 - ASBMB
So far some nuclear receptors for bile acids have been identified. However, no cell surface
receptor for bile acids has yet been reported. We found that a novel G protein-coupled
receptor, TGR5, is responsive to bile acids as a cell-surface receptor. Bile acids specifically
induced receptor internalization, the activation of extracellular signal-regulated kinase
mitogen-activated protein kinase, the increase of guanosine 5′-O-3-thio-triphosphate
binding in membrane fractions, and intracellular cAMP production in Chinese hamster ovary …