Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
A Vrieze, C Out, S Fuentes, L Jonker, I Reuling… - Journal of …, 2014 - Elsevier
Background & Aims Obesity has been associated with changes in the composition and
function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters
bile acid and glucose metabolism in mice. Hence, we hypothesized that short term
administration of oral antibiotics in humans would affect fecal microbiota composition and
subsequently bile acid and glucose metabolism. Methods In this single blinded randomized
controlled trial, 20 male obese subjects with metabolic syndrome were randomized to 7 days …
function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters
bile acid and glucose metabolism in mice. Hence, we hypothesized that short term
administration of oral antibiotics in humans would affect fecal microbiota composition and
subsequently bile acid and glucose metabolism. Methods In this single blinded randomized
controlled trial, 20 male obese subjects with metabolic syndrome were randomized to 7 days …