[HTML][HTML] HER2/Neu-and TAK1-mediated up-regulation of the transforming growth factor β inhibitor Smad7 via the ETS protein ER81

SC Dowdy, A Mariani, R Janknecht - Journal of Biological Chemistry, 2003 - ASBMB
The cytokine transforming growth factor β (TGF-β) plays an important role in preventing
tumor formation by blocking cell cycle progression. Accordingly, many cancers demonstrate
mutations in TGF-β signaling components or enhanced expression of inhibitors of the TGF-β
pathway such as Smad7. In this report we show that the oncoprotein HER2/Neu is able to
collaborate with the ETS transcription factor ER81 to activate Smad7 transcription in breast,
endometrial, and ovarian cancer cell lines. ER81 binds to two ETS sites within the Smad7 …