[HTML][HTML] Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A
J Wu, R Janknecht - Journal of Biological Chemistry, 2002 - ASBMB
The ETS transcription factor ER81 is activated in response to many signals via mitogen-
activated protein kinases (MAPKs). However, ER81 is not only phosphorylated on MAPK
sites but also at other sites that impact on its transactivation potential. Here we describe that
the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular
signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and
enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within …
activated protein kinases (MAPKs). However, ER81 is not only phosphorylated on MAPK
sites but also at other sites that impact on its transactivation potential. Here we describe that
the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular
signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and
enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within …