[HTML][HTML] Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells
D Hakuno, T Takahashi, J Lammerding… - Journal of Biological …, 2005 - ASBMB
The signaling steps that induce cardiac differentiation in embryonic stem (ES) cells are
incompletely understood. We examined the effect of adhesion signaling including Src and
focal adhesion kinase (FAK) on cardiogenesis in mouse ES cells using α-myosin heavy
chain promoter-driven enhanced green fluorescent protein or luciferase as reporters.
Cardiac transcription factors including Nkx2. 5 and Tbx5 mRNA were first expressed at day 4
in hanging drop embryoid bodies, and adhesion of embryoid bodies to surfaces at or before …
incompletely understood. We examined the effect of adhesion signaling including Src and
focal adhesion kinase (FAK) on cardiogenesis in mouse ES cells using α-myosin heavy
chain promoter-driven enhanced green fluorescent protein or luciferase as reporters.
Cardiac transcription factors including Nkx2. 5 and Tbx5 mRNA were first expressed at day 4
in hanging drop embryoid bodies, and adhesion of embryoid bodies to surfaces at or before …