[HTML][HTML] Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development

A Davy, P Soriano - Developmental biology, 2007 - Elsevier
Developmental biology, 2007Elsevier
Genetic studies in the mouse have implicated ephrin-B2 (encoded by the gene Efnb2) in
blood vessel formation, cardiac development and remodeling of the lymphatic vasculature.
Here we report that loss of ephrin-B2 leads to defects in populations of cranial and trunk
neural crest cells (NCC) and to defective somite development. In addition, we show that
Efnb1/Efnb2 double heterozygous embryos exhibit phenotypes in a number of NCC
derivatives. Expression of one copy of a mutant version of Efnb2 that lacks tyrosine …
Genetic studies in the mouse have implicated ephrin-B2 (encoded by the gene Efnb2) in blood vessel formation, cardiac development and remodeling of the lymphatic vasculature. Here we report that loss of ephrin-B2 leads to defects in populations of cranial and trunk neural crest cells (NCC) and to defective somite development. In addition, we show that Efnb1/Efnb2 double heterozygous embryos exhibit phenotypes in a number of NCC derivatives. Expression of one copy of a mutant version of Efnb2 that lacks tyrosine phosphorylation sites was sufficient to rescue the embryonic phenotypes associated with loss of Efnb2. Our results uncover an important role for ephrin-B2 in NCC and somites during embryogenesis and suggest that ephrin-B2 exerts many of its embryonic function via activation of forward signaling.
Elsevier