A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system

I Comerford, Y Harata-Lee, MD Bunting… - Cytokine & growth factor …, 2013 - Elsevier
The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of
migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of
T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However,
CCR7 and its ligands also contribute to a multitude of adaptive immune functions including
thymocyte development, secondary lymphoid organogenesis, high affinity antibody
responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In …