Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration
MC Bosco, M Puppo, F Blengio, T Fraone, P Cappello… - Immunobiology, 2008 - Elsevier
A common denominator of several pathological conditions, such as solid tumors and
inflammatory lesions, is represented by low partial oxygen pressure (pO2) 2. Mononuclear
phagocytes are recruited in large numbers as primary monocytes from the circulation to
diseased tissues, where they accumulate within ischemic/hypoxic sites terminally
differentiating into inflammatory and tumor-associated macrophages or myeloid dendritic
cells (DCs). Thus, mononuclear phagocyte responses that ensue at pathological sites begin …
inflammatory lesions, is represented by low partial oxygen pressure (pO2) 2. Mononuclear
phagocytes are recruited in large numbers as primary monocytes from the circulation to
diseased tissues, where they accumulate within ischemic/hypoxic sites terminally
differentiating into inflammatory and tumor-associated macrophages or myeloid dendritic
cells (DCs). Thus, mononuclear phagocyte responses that ensue at pathological sites begin …