Role of interleukin 1 in atopic dermatitis

W Abramovits, JJR Bejarano… - Dermatologic …, 2013 - derm.theclinics.com
Interleukin-1 (IL-1) is a potent inflammatory cytokine that plays a central role in the innate
immune response. 1 Discovered in the 1970s, it was initially named lymphocyte-activating
factor, catabolin, and endogenous pyrogen because of its proinflammatory effects. 2 IL-1
mediates the acute phase of inflammation by inducing local and systemic responses, such
as pain sensitivity, fever, vasodilation, and hypotension. It also promotes the expression of
adhesion molecules on endothelial cells, which allows the infiltration of inflammatory and …