Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum
M Yokouchi, A Kubo, H Kawasaki, K Yoshida… - Journal of …, 2015 - Elsevier
Background The tight junction (TJ) barrier is located in the granular layer of the epidermis.
Filaggrin deficiency predisposes patients to atopic dermatitis (AD) by impairing stratum
corneum (SC) barrier function. Altered TJ barrier function has been observed in the skin of
patients with AD; however, it remains unclear whether TJ function is influenced by filaggrin
deficiency directly or secondarily via skin inflammation. Objective To investigate the in vivo
effects of filaggrin deficiency and skin inflammation on epidermal TJ function. Methods …
Filaggrin deficiency predisposes patients to atopic dermatitis (AD) by impairing stratum
corneum (SC) barrier function. Altered TJ barrier function has been observed in the skin of
patients with AD; however, it remains unclear whether TJ function is influenced by filaggrin
deficiency directly or secondarily via skin inflammation. Objective To investigate the in vivo
effects of filaggrin deficiency and skin inflammation on epidermal TJ function. Methods …