Cellular senescence: when bad things happen to good cells

J Campisi, F d'Adda di Fagagna - Nature reviews Molecular cell biology, 2007 - nature.com
Nature reviews Molecular cell biology, 2007nature.com
Cells continually experience stress and damage from exogenous and endogenous sources,
and their responses range from complete recovery to cell death. Proliferating cells can
initiate an additional response by adopting a state of permanent cell-cycle arrest that is
termed cellular senescence. Understanding the causes and consequences of cellular
senescence has provided novel insights into how cells react to stress, especially genotoxic
stress, and how this cellular response can affect complex organismal processes such as the …
Abstract
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.
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