[HTML][HTML] Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells

S Pei, M Minhajuddin, KP Callahan, M Balys… - Journal of Biological …, 2013 - ASBMB
The development of strategies to eradicate primary human acute myelogenous leukemia
(AML) cells is a major challenge to the leukemia research field. In particular, primitive
leukemia cells, often termed leukemia stem cells, are typically refractory to many forms of
therapy. To investigate improved strategies for targeting of human AML cells we compared
the molecular mechanisms regulating oxidative state in primitive (CD34+) leukemic versus
normal specimens. Our data indicate that CD34+ AML cells have elevated expression of …