Receptor-mediated angiotensin II transcytosis by brain microvessel endothelial cells
JM Rose, KL Audus - Peptides, 1998 - Elsevier
Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel
endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable
with a Km of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport
being greater.[3H] Ang II transport was found to be inhibited by excess unlabeled Ang II, by
the Ang II analog sarathrin, and by the endocytic inhibitor phenylarsine oxide. Ang II-(2–8)
and-(3–8) were shown to significantly increase the transport of Ang II. These results …
endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable
with a Km of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport
being greater.[3H] Ang II transport was found to be inhibited by excess unlabeled Ang II, by
the Ang II analog sarathrin, and by the endocytic inhibitor phenylarsine oxide. Ang II-(2–8)
and-(3–8) were shown to significantly increase the transport of Ang II. These results …