[HTML][HTML] The human leukocyte antigen–presented ligandome of B lymphocytes

C Hassan, MGD Kester, AH de Ru, P Hombrink… - Molecular & Cellular …, 2013 - ASBMB
Peptides presented by human leukocyte antigen (HLA) molecules on the cell surface play a
crucial role in adaptive immunology, mediating the communication between T cells and
antigen presenting cells. Knowledge of these peptides is of pivotal importance in
fundamental studies of T cell action and in cellular immunotherapy and transplantation. In
this paper we present the in-depth identification and relative quantification of 14,500 peptide
ligands constituting the HLA ligandome of B cells. This large number of identified ligands …