The interdependence of transcript and protein abundance: new data–new complexities
Y Liu, R Aebersold - Molecular systems biology, 2016 - embopress.org
Molecular systems biology, 2016•embopress.org
The relative contribution of transcriptional and translational regulation in gene expression
control has been intensely debated and remains a challenging question. Recent reports
have suggested that protein abundance in mammalian cells is primarily controlled at the
transcript‐level. In their recent work, Cheng et al (2016) determined the proteomic and
transcriptomic changes in cells responding to endoplasmic reticulum (ER) stress. Their
analyses indicate that the ER stress response is significantly controlled at both the transcript …
control has been intensely debated and remains a challenging question. Recent reports
have suggested that protein abundance in mammalian cells is primarily controlled at the
transcript‐level. In their recent work, Cheng et al (2016) determined the proteomic and
transcriptomic changes in cells responding to endoplasmic reticulum (ER) stress. Their
analyses indicate that the ER stress response is significantly controlled at both the transcript …
The relative contribution of transcriptional and translational regulation in gene expression control has been intensely debated and remains a challenging question. Recent reports have suggested that protein abundance in mammalian cells is primarily controlled at the transcript‐level. In their recent work, Cheng et al (2016) determined the proteomic and transcriptomic changes in cells responding to endoplasmic reticulum (ER) stress. Their analyses indicate that the ER stress response is significantly controlled at both the transcript and protein levels.
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