Oncogenic roles of EMT-inducing transcription factors

A Puisieux, T Brabletz, J Caramel - Nature cell biology, 2014 - nature.com
A Puisieux, T Brabletz, J Caramel
Nature cell biology, 2014nature.com
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal
transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel
both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing
transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability
to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive …
Abstract
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.
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