[HTML][HTML] Cytosolic dynamics of annexin A6 trigger feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes

P Banerjee, A Bandyopadhyay - Journal of Biological Chemistry, 2014 - ASBMB
Malfunctions in regulatory pathways that control cell size are prominent in pathological
cardiac hypertrophy. Here, we show annexin A6 (Anxa6) to be a crucial regulator of atrial
natriuretic peptide (ANP)-mediated counterhypertrophic responses in cardiomyocytes.
Adrenergic stimulation of H9c2 cardiomyocytes by phenylephrine (PE) increased the cell
size with enhanced expression of biochemical markers of hypertrophy, concomitant with
elevated expression and subcellular redistribution of Anxa6. Stable cell lines with controlled …