Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors
GJ Gores, SH Kaufmann - Genes & development, 2012 - genesdev.cshlp.org
Genes & development, 2012•genesdev.cshlp.org
Bcl-2, Bcl-xL, Mcl-1, and A1 are the predominant anti-apoptotic members of the Bcl-2 family
in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-xL for
survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of
Genes & Development (pp. 120–125) demonstrates that Mcl-1 is essential for development
and survival of acute myelogenous leukemia cells. These results provide new impetus for
the generation of selective Mcl-1 inhibitors.
in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-xL for
survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of
Genes & Development (pp. 120–125) demonstrates that Mcl-1 is essential for development
and survival of acute myelogenous leukemia cells. These results provide new impetus for
the generation of selective Mcl-1 inhibitors.
Bcl-2, Bcl-xL, Mcl-1, and A1 are the predominant anti-apoptotic members of the Bcl-2 family in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-xL for survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of Genes & Development (pp. 120–125) demonstrates that Mcl-1 is essential for development and survival of acute myelogenous leukemia cells. These results provide new impetus for the generation of selective Mcl-1 inhibitors.
genesdev.cshlp.org