Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
J LoPiccolo, GM Blumenthal, WB Bernstein… - Drug Resistance …, 2008 - Elsevier
The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor
suppressor PTEN function, amplification or mutation of PI3K, amplification or mutation of Akt,
activation of growth factor receptors, and exposure to carcinogens. Once activated, signaling
through Akt can be propagated to a diverse array of substrates, including mTOR, a key
regulator of protein translation. This pathway is an attractive therapeutic target in cancer …
in many types of cancer. Mechanisms for pathway activation include loss of tumor
suppressor PTEN function, amplification or mutation of PI3K, amplification or mutation of Akt,
activation of growth factor receptors, and exposure to carcinogens. Once activated, signaling
through Akt can be propagated to a diverse array of substrates, including mTOR, a key
regulator of protein translation. This pathway is an attractive therapeutic target in cancer …