Type I IFN–a blunt spear in fighting HIV-1 infection
C Acchioni, G Marsili, E Perrotti, AL Remoli… - Cytokine & growth factor …, 2015 - Elsevier
For more than 50 years, Type I Interferon (IFN) has been recognized as critical in controlling
viral infections. IFN is produced downstream germ-line encoded pattern recognition
receptors (PRRs) upon engagement by pathogen-associated molecular patterns (PAMPs).
As a result, hundreds of different interferon-stimulated genes (ISGs) are rapidly induced,
acting in both autocrine and paracrine manner to build a barrier against viral replication and
spread. ISGs encode proteins with direct antiviral and immunomodulatory activities affecting …
viral infections. IFN is produced downstream germ-line encoded pattern recognition
receptors (PRRs) upon engagement by pathogen-associated molecular patterns (PAMPs).
As a result, hundreds of different interferon-stimulated genes (ISGs) are rapidly induced,
acting in both autocrine and paracrine manner to build a barrier against viral replication and
spread. ISGs encode proteins with direct antiviral and immunomodulatory activities affecting …