The pathogenesis of the bone disease of multiple myeloma
CM Edwards, J Zhuang, GR Mundy - Bone, 2008 - Elsevier
CM Edwards, J Zhuang, GR Mundy
Bone, 2008•ElsevierMultiple myeloma is a fatal hematologic malignancy associated with clonal expansion of
malignant plasma cells within the bone marrow and the development of a destructive
osteolytic bone disease. The principal cellular mechanisms involved in the development of
myeloma bone disease are an increase in osteoclastic bone resorption, and a reduction in
bone formation. Myeloma cells are found in close association with sites of active bone
resorption, and the interactions between myeloma cells and other cells within the …
malignant plasma cells within the bone marrow and the development of a destructive
osteolytic bone disease. The principal cellular mechanisms involved in the development of
myeloma bone disease are an increase in osteoclastic bone resorption, and a reduction in
bone formation. Myeloma cells are found in close association with sites of active bone
resorption, and the interactions between myeloma cells and other cells within the …
Multiple myeloma is a fatal hematologic malignancy associated with clonal expansion of malignant plasma cells within the bone marrow and the development of a destructive osteolytic bone disease. The principal cellular mechanisms involved in the development of myeloma bone disease are an increase in osteoclastic bone resorption, and a reduction in bone formation. Myeloma cells are found in close association with sites of active bone resorption, and the interactions between myeloma cells and other cells within the specialized bone marrow microenvironment are essential, both for tumor growth and the development of myeloma bone disease. This review discusses the many different factors which have been implicated in myeloma bone disease, including the evidence for their role in myeloma and subsequent therapeutic implications.
Elsevier