Fish in a dish: drug discovery for hearing habilitation
R Esterberg, AB Coffin, H Ou, JA Simon… - Drug Discovery Today …, 2013 - Elsevier
The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The
identification of drugs that modulate the susceptibility to hair cell loss or spur their
regeneration is often hampered by the difficulties of assaying for such complex phenomena
in mammalian models. The zebrafish has emerged as a powerful animal model for chemical
screening in many contexts. Several characteristics of the zebrafish, such as its small size
and external location of sensory hair cells, uniquely position it as an ideal model organism …
identification of drugs that modulate the susceptibility to hair cell loss or spur their
regeneration is often hampered by the difficulties of assaying for such complex phenomena
in mammalian models. The zebrafish has emerged as a powerful animal model for chemical
screening in many contexts. Several characteristics of the zebrafish, such as its small size
and external location of sensory hair cells, uniquely position it as an ideal model organism …