Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line

HC Ou, DW Raible, EW Rubel - Hearing research, 2007 - Elsevier
We have used time-lapse imaging to study cisplatin-induced hair cell death in lateral line
neuromasts of zebrafish larvae in vivo. We found that cisplatin-induced hair cell death
occurred much more slowly than had been shown to occur in aminoglycoside-induced hair
cell death. By prelabeling hair cells with FM1-43FX, and assessing hair cell damage, it was
established that cisplatin causes hair cell loss in the lateral line in a dose-dependent
fashion. The kinetics of hair cell loss during exposure to different concentrations of cisplatin …