Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways
KN Owens, AB Coffin, LS Hong, KOC Bennett… - Hearing research, 2009 - Elsevier
We report a series of experiments investigating the kinetics of hair cell loss in lateral line
neuromasts of zebrafish larvae following exposure to aminoglycoside antibiotics.
Comparisons of the rate of hair cell loss and the differential effects of acute versus chronic
exposure to gentamicin and neomycin revealed markedly different results. Neomycin
induced rapid and dramatic concentration-dependent hair cell loss that is essentially
complete within 90min, regardless of concentration or exposure time. Gentamicin-induced …
neuromasts of zebrafish larvae following exposure to aminoglycoside antibiotics.
Comparisons of the rate of hair cell loss and the differential effects of acute versus chronic
exposure to gentamicin and neomycin revealed markedly different results. Neomycin
induced rapid and dramatic concentration-dependent hair cell loss that is essentially
complete within 90min, regardless of concentration or exposure time. Gentamicin-induced …