[HTML][HTML] Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside is independent of AMP-activated protein kinase …
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr), a commonly used indirect
activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC)
biosynthesis in freshly isolated hepatocytes. In all nucleated mammalian cells, PC is
synthesized from choline via the Kennedy (CDP-choline) pathway. The purpose of our study
was to provide direct evidence that AMPK regulates phospholipid biosynthesis and to
elucidate the mechanism (s) by which AMPK inhibits hepatic PC synthesis. Incubations of …
activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC)
biosynthesis in freshly isolated hepatocytes. In all nucleated mammalian cells, PC is
synthesized from choline via the Kennedy (CDP-choline) pathway. The purpose of our study
was to provide direct evidence that AMPK regulates phospholipid biosynthesis and to
elucidate the mechanism (s) by which AMPK inhibits hepatic PC synthesis. Incubations of …