[PDF][PDF] Mutant p53 in cancer: new functions and therapeutic opportunities
PAJ Muller, KH Vousden - Cancer cell, 2014 - cell.com
PAJ Muller, KH Vousden
Cancer cell, 2014•cell.comMany different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have
both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute
to malignant progression. Understanding the functions of mutant p53 will help in the
development of new therapeutic approaches that may be useful in a broad range of cancer
types.
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have
both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute
to malignant progression. Understanding the functions of mutant p53 will help in the
development of new therapeutic approaches that may be useful in a broad range of cancer
types.
Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.
cell.com