Signaling mechanisms that regulate smooth muscle cell differentiation

CP Mack - Arteriosclerosis, thrombosis, and vascular biology, 2011 - Am Heart Assoc
CP Mack
Arteriosclerosis, thrombosis, and vascular biology, 2011Am Heart Assoc
Extensive studies over the last 30 years have demonstrated that vascular smooth muscle
cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of
environmental cues. The identification of the signaling mechanisms by which these
environmental cues regulate SMC phenotype has been more difficult because of our
incomplete knowledge of the transcription mechanisms that regulate SMC-specific gene
expression. However, recent advances in this area have provided significant insight, and the …
Extensive studies over the last 30 years have demonstrated that vascular smooth muscle cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of environmental cues. The identification of the signaling mechanisms by which these environmental cues regulate SMC phenotype has been more difficult because of our incomplete knowledge of the transcription mechanisms that regulate SMC-specific gene expression. However, recent advances in this area have provided significant insight, and the goal of this review is to summarize the signaling mechanisms by which extrinsic cues control SMC differentiation.
Am Heart Assoc