[HTML][HTML] Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating protein (Rho-GAP), GRAF1
JT Doherty, KC Lenhart, MV Cameron, CP Mack… - Journal of Biological …, 2011 - ASBMB
Although RhoA activity is necessary for promoting myogenic mesenchymal stem cell fates,
recent studies in cultured cells suggest that down-regulation of RhoA activity in specified
myoblasts is required for subsequent differentiation and myotube formation. However,
whether this phenomenon occurs in vivo and which Rho modifiers control these later events
remain unclear. We found that expression of the Rho-GTPase-activating protein, GRAF1,
was transiently up-regulated during myogenesis, and studies in C2C12 cells revealed that …
recent studies in cultured cells suggest that down-regulation of RhoA activity in specified
myoblasts is required for subsequent differentiation and myotube formation. However,
whether this phenomenon occurs in vivo and which Rho modifiers control these later events
remain unclear. We found that expression of the Rho-GTPase-activating protein, GRAF1,
was transiently up-regulated during myogenesis, and studies in C2C12 cells revealed that …