Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA–induced dyskinesia and histone activation
S Darmopil, AB Martín, IR De Diego, S Ares… - Biological …, 2009 - Elsevier
BACKGROUND: Pharmacologic studies have implicated dopamine D1-like receptors in the
development of dopamine precursor molecule 3, 4-dihydroxyphenyl-L-alanine (L-DOPA)-
induced dyskinesias and associated molecular changes in hemiparkinsonian mice.
However, pharmacologic agents for D1 or D2 receptors also recognize other receptor family
members. Genetic inactivation of the dopamine D1 or D2 receptor was used to define the
involvement of these receptor subtypes. METHODS: During a 3-week period of daily L …
development of dopamine precursor molecule 3, 4-dihydroxyphenyl-L-alanine (L-DOPA)-
induced dyskinesias and associated molecular changes in hemiparkinsonian mice.
However, pharmacologic agents for D1 or D2 receptors also recognize other receptor family
members. Genetic inactivation of the dopamine D1 or D2 receptor was used to define the
involvement of these receptor subtypes. METHODS: During a 3-week period of daily L …