Dopaminergic modulation of striatal networks in health and Parkinson's disease
DJ Surmeier, SM Graves, W Shen - Current opinion in neurobiology, 2014 - Elsevier
DJ Surmeier, SM Graves, W Shen
Current opinion in neurobiology, 2014•ElsevierHighlights•Spiny projection neurons do not just differ in their expression of dopamine
receptors.•The signaling mechanisms controlling synaptic plasticity are diverse.•Cholinergic
interneurons play an unexpected role in dopamine release.•Aberrant synaptic plasticity is
central to levodopa-induced dyskinesia.In the last couple of years, there have been
significant advances in our understanding of how dopamine modulates striatal circuits
underlying goal-directed behaviors and how therapeutic interventions intended to normalize …
receptors.•The signaling mechanisms controlling synaptic plasticity are diverse.•Cholinergic
interneurons play an unexpected role in dopamine release.•Aberrant synaptic plasticity is
central to levodopa-induced dyskinesia.In the last couple of years, there have been
significant advances in our understanding of how dopamine modulates striatal circuits
underlying goal-directed behaviors and how therapeutic interventions intended to normalize …
Highlights
- Spiny projection neurons do not just differ in their expression of dopamine receptors.
- The signaling mechanisms controlling synaptic plasticity are diverse.
- Cholinergic interneurons play an unexpected role in dopamine release.
- Aberrant synaptic plasticity is central to levodopa-induced dyskinesia.
In the last couple of years, there have been significant advances in our understanding of how dopamine modulates striatal circuits underlying goal-directed behaviors and how therapeutic interventions intended to normalize disordered dopaminergic signaling can go awry. This review summarizes some of the advances in this field with a translational focus on Parkinson's disease.
Elsevier