[HTML][HTML] Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1

GR Campbell, RS Bruckman, YL Chu… - Journal of Biological …, 2015 - ASBMB
Histone deacetylase inhibitors (HDACi) are being evaluated in a" shock-and-kill" therapeutic
approach to reverse human immunodeficiency virus type-1 (HIV) latency from CD4+ T cells.
Using this approach, HDACi have induced HIV RNA synthesis in latently infected cells from
some patients. The hope is that the increase in viral production will lead to killing of the
infected cell either by the virus itself or by the patient's immune system, a" sterilizing cure."
Although administered within the context of combination antiretroviral therapy, the infection …