New insights into innate immune restriction of West Nile virus infection
HM Lazear, MS Diamond - Current opinion in virology, 2015 - Elsevier
Highlights•Genetic screens have identified host factors restricting WNV infection in
cells.•WNV infection paradoxically is restricted by cGAS, a DNA sensor.•Interferon-α/β
tightens the blood–brain barrier, which limits WNV neuroinvasion.West Nile virus (WNV) is
an encephalitic flavivirus that has provided a valuable experimental system for studying viral
pathogenesis and immunity. Although in vitro approaches and mouse models of infection
have identified pattern recognition receptor and interferon pathways that control WNV …
cells.•WNV infection paradoxically is restricted by cGAS, a DNA sensor.•Interferon-α/β
tightens the blood–brain barrier, which limits WNV neuroinvasion.West Nile virus (WNV) is
an encephalitic flavivirus that has provided a valuable experimental system for studying viral
pathogenesis and immunity. Although in vitro approaches and mouse models of infection
have identified pattern recognition receptor and interferon pathways that control WNV …