Distribution of ten laminin chains in dystrophic and regenerating muscles

BL Patton, AM Connolly, PT Martin… - Neuromuscular …, 1999 - Elsevier
Using immunohistochemical methods, we assessed the distribution of all 10 known laminin
chains (α1-5, β1-3, γ1 and γ2) in skeletal muscles from patients with Duchenne, congenital,
limb girdle, or Emery–Dreifuss muscular dystrophies. The α2, β1 and γ1 chains were
abundant in the basal lamina surrounding muscle fibers in normal controls; α1, α3–α5, β3,
and γ2 were undetectable; and β2 was present at a low level. Compared to controls, levels
of the α5 chain were increased in muscles from many dystrophic patients; levels of β1 were …