Retinoblastoma is the most common neoplasm of the eye in childhood, representing 2.5% to
4% of all pediatric cancers. The average age-adjusted incidence rate of retinoblastoma in
the United States and Europe is 2 to 5 per million children (approximately 1 in 14,000–
18,000 live births). 1, 2 Retinoblastoma is a cancer of the very young; two-thirds are
diagnosed before 2 years of age, and 95% before 5 years. 1 Retinoblastoma presents in 2
distinct clinical forms:(1) a bilateral or multifocal, heritable form (25% of all cases) …