Vascular endothelial cells (ECs) are ideal gene therapy targets as they provide widespread
tissue access and are the first contact surfaces following intravenous vector administration.
Human recombinant adenovirus serotype 5 (Ad5) is the most frequently used gene transfer
system because of its appreciable transgene payload capacity and lack of somatic mutation
risk. However, standard Ad5 vectors predominantly transduce liver but not the vasculature
following intravenous administration. We recently developed an Ad5 vector with a myeloid …