[HTML][HTML] Autophagy controls IL-1β secretion by targeting pro-IL-1β for degradation
J Harris, M Hartman, C Roche, SG Zeng… - Journal of Biological …, 2011 - ASBMB
Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-
associated molecules and recently has been shown to influence IL-1β secretion by
macrophages. However, the mechanisms behind this are unclear. Here, we describe a
novel role for autophagy in regulating the production of IL-1β in antigen-presenting cells.
After treatment of macrophages with Toll-like receptor ligands, pro-IL-1β was specifically
sequestered into autophagosomes, whereas further activation of autophagy with rapamycin …
associated molecules and recently has been shown to influence IL-1β secretion by
macrophages. However, the mechanisms behind this are unclear. Here, we describe a
novel role for autophagy in regulating the production of IL-1β in antigen-presenting cells.
After treatment of macrophages with Toll-like receptor ligands, pro-IL-1β was specifically
sequestered into autophagosomes, whereas further activation of autophagy with rapamycin …