The Reeler heterozygous mice (reln+/−) are haplodeficient in the gene (reln) encoding for
the reelin glycoprotein (RELN) and display reductions in brain/peripheral RELN similar to
autistic or schizophrenic patients. Cytoarchitectonic alterations of the reln+/− brain may be
subtle, and are difficult to demonstrate by current histological approaches. We analyzed the
number and topological organization of the Purkinje neurons (PNs) in five vermal lobules–
central (II–III), culmen (IV–V), tuber (VIIb), uvula (IX), and nodulus (X)–that process different …