The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family

G Bu - International review of cytology, 2001 - Elsevier
Members of the LDL receptor family mediate endocytosis and signal transduction of many
extracellular ligands which participate in lipoprotein metabolism, protease regulation,
embryonic development, and the pathogenesis of disease (eg, Alzheimer's disease).
Structurally, these receptors share common motifs and modules that are highlighted with
clusters of cysteine-rich ligand-binding repeats. Perhaps, the most significant feature that is
shared by members of the LDL receptor family is the ability of a 39-kDa receptor-associated …