[HTML][HTML] Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin
A Betz, M Okamoto, F Benseler, N Brose - Journal of Biological Chemistry, 1997 - ASBMB
unc-13 mutants in Caenorhabditis elegans are characterized by a severe deficit in
neurotransmitter release. Their phenotype is similar to that of the C. elegans unc-18
mutation, which is thought to affect synaptic vesicle docking to the active zone. This suggests
a crucial role for the unc-13 gene product in the mediation or regulation of synaptic vesicle
exocytosis. Munc13-1 is one of three closely related rat homologues of unc-13. Based on the
high degree of similarity between unc-13 and Munc13 proteins, it is thought that their …
neurotransmitter release. Their phenotype is similar to that of the C. elegans unc-18
mutation, which is thought to affect synaptic vesicle docking to the active zone. This suggests
a crucial role for the unc-13 gene product in the mediation or regulation of synaptic vesicle
exocytosis. Munc13-1 is one of three closely related rat homologues of unc-13. Based on the
high degree of similarity between unc-13 and Munc13 proteins, it is thought that their …