FOXP1 and estrogen signaling in breast cancer

N Ijichi, K Ikeda, K Horie-Inoue, S Inoue - Vitamins & Hormones, 2013 - Elsevier
Breast cancers are considered to be primarily regulated by estrogen signaling pathways
because estrogen-dependent proliferation is observed in the majority of breast cancer
cases. Thus, hormone therapy using antiestrogen drugs such as tamoxifen is effective for
breast cancers expressing estrogen receptor α (ERα). However, acquired resistance during
the endocrine therapy is a critical unresolved problem in breast cancer. Recently, a forkhead
transcription factor FOXA1 has been reported to play an important role in the regulation of …