Molecular regulation of the pore component of CRAC channels, Orai1
S Srikanth, Y Gwack - Current topics in membranes, 2013 - Elsevier
Abstract Store-operated Ca 2+ entry (SOCE) is a fundamental mechanism ubiquitously
employed by cells to elevate intracellular Ca 2+ concentrations ([Ca 2+] i). Increased
intracellular Ca 2+ ions act as a second messenger that can stimulate a variety of
downstream signaling pathways affecting proliferation, secretion, differentiation, and death
of cells. In immune cells, immune receptor stimulation induces endoplasmic reticulum Ca 2+
store depletion that subsequently activates Ca 2+-release-activated-Ca 2+(CRAC) …
employed by cells to elevate intracellular Ca 2+ concentrations ([Ca 2+] i). Increased
intracellular Ca 2+ ions act as a second messenger that can stimulate a variety of
downstream signaling pathways affecting proliferation, secretion, differentiation, and death
of cells. In immune cells, immune receptor stimulation induces endoplasmic reticulum Ca 2+
store depletion that subsequently activates Ca 2+-release-activated-Ca 2+(CRAC) …