[36] Fourier transform infrared spectroscopy in analysis of protein deposits

S Seshadri, R Khurana, AL Fink - Methods in enzymology, 1999 - Elsevier
Publisher Summary The intrinsic insoluble nature of protein deposits (as in amorphous
aggregates, inclusion bodies, amyloid fibrils, etc.) places severe restrictions on the
availability of methods required for ascertaining the structure of the material. Fourier
transform infrared (FTIR) spectroscopy is well suited for determining structural features of
proteins, both in solution and as deposits. Proteins in the form of solutions, thin films
(hydrated or dry), solids (including lyophilized or spray-dried powders), or suspensions of …