[HTML][HTML] Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal …
K Uchio, B Tuchweber, N Manabe, G Gabbiani… - Laboratory …, 2002 - Elsevier
Abstract Cellular retinol-binding protein-1 (CRBP-1) is involved in vitamin A metabolism
because it mediates both retinol esterification to retinyl esters and retinol oxidation to retinal
and retinoic acid. CRBP-1 is highly expressed in the liver, particularly in hepatic stellate cells
(HSC). In this study, we investigated the liver expression of CRBP-1 during experimental
fibrogenesis. We also studied the regulation of CRBP-1 expression in cultured HSC and
portal fibroblasts, two fibroblastic cell types involved in liver fibrogenesis. Fibrosis was …
because it mediates both retinol esterification to retinyl esters and retinol oxidation to retinal
and retinoic acid. CRBP-1 is highly expressed in the liver, particularly in hepatic stellate cells
(HSC). In this study, we investigated the liver expression of CRBP-1 during experimental
fibrogenesis. We also studied the regulation of CRBP-1 expression in cultured HSC and
portal fibroblasts, two fibroblastic cell types involved in liver fibrogenesis. Fibrosis was …