Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis

GP DE LEMA, H Maier, E Nieto… - Journal of the …, 2001 - journals.lww.com
Lupus nephritis is characterized by immune complex deposition and inflammatory cell
infiltration. Therefore, the initiation and progression of lupus nephritis in MRL/MpJ Fas lpr/lpr
(MRL/lpr) mice were investigated, with a focus on the expression of several chemokines and
chemokine receptors. Mice were monitored for proteinuria from 6 to 20 wk of age, and
kidneys were examined every 2 wk by light microscopy, electron microscopy, and
immunohistologic analyses. Furthermore, the expression of chemokines, chemokine …